Isaac Brekken, AP
The video, which includes several St. Jude patients, as well as doctors, nurses and other medical personnel, also features Jennifer Aniston, Ellen DeGeneres, Dr. Oz, Jimmy Kimmel, Jordin Sparks, Betty White, Michael Jordan, Robin Williams and many more.
The clip honors 50 years of St. Jude's efforts in researching and treating childhood cancer and other diseases. It's a cause John Rich is proud to stand behind.
"St. Jude Children's Research Hospital holds a very special place in my heart," the singer explains. "I don't know how you could spend your time any better on this earth than to support something like St. Jude. It's truly God's work."
Earlier this year, John hosted a star-studded benefit which included Darius, Kellie Pickler and Jeff Foxworthy. In 2011, he raised more than $1 million for St. Jude by winning the 11th season of "Celebrity Apprentice."
Watch the heartwarming video below, and click here to make a donation to St. Jude Children's Research Hospital.
Watch a Report on the Patients of St. Jude